Artwork by Annie Spikes and Katya Kadyshevskaya

 

* corresponding author,  $ co-first author

• Structural pharmacology and therapeutic potential of 5-methoxytryptamines
  Nature (2024), DOI: 10.1038/s41586-024-07403-2
  ^$Warren AL, ^$Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, *Sames D,^*Wacker D
• Structural insights into the unexpected agonism of tetracyclic antidepressants at serotonin receptors 5-HT1eR and 5-HT1FR 
  Sci Adv (2024), DOI: 10.1126/sciadv.adk4855
  ^$Zilberg G, ^$Parpounas AK, ^$Warren AL, Fiorillo B, Provasi D, Filizola M, ^*Wacker D
• Molecular basis of human trace amine-associated receptor I activation
  Nat Commun 15, 108, (2024)
  ​^*Zilberg G, Parpounas AK, Warren AL, Yang S, ^*Wacker D
• Molecular insights into GPCR mechanisms of drugs of abuse
  J Biol Chem 299, 105176, (2023)
  ​^$Sanchez-Reyes OB, ^$Zilberg G, *McCorvy JD, ^*Wacker D
• Substrate binding and inhibition of the anion exchanger 1 transporter
  Nat Struct Mol Biol 30, 1495-1504, (2023)
  ​^$Capper MJ, ^$Yang S, ^$Stone AC, Vatansever S, Zilberg G, Mathiharan YK, Habib R, Hutchinson K, Schlessinger A, Mezei M, Osman R, Zhang B, ^*Wacker D
• A regional and projection-specific role of RGSz1 in the ventrolateral periaqueductal grey in the modulation of morphine reward
  Mol Pharmacol 103, 1-8, (2023)
  ​^$Sakloth F, ^$Sanchez-Reyes OB, Pryce KD, Ruiz A, Serafini RA, Bertherat F, Gomes I, Devi L, ^*Wacker D, ^*Zachariou V
• Artificial intelligence and machine learning-aided drug discovery in central nervous system diseases: State-of-the-arts and future directions
  Med Res Rev 41, 1427-1473, (2021)
  Vatansever S, Schlessinger A, Wacker D, Kaniskan HÜ, Jin J, Zhou MM, ^*Zhang B
• Structure of a hallucinogen-activated Gq-coupled 5-HT2A serotonin receptor
  Cell 182, 1574-1588, (2020)
  ^$Kim K, ^$Che T, ^$Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, *Skiniotis G, *Roth BL
• Sampling the host response to SARS-CoV-2 in hospitals under siege
  Nat Med 26, 1157-1158, (2020)
  *Charney AW, Simons NW, Mouskas K, Lepow L, Cheng E, Le Berichel J, Chang C, Marvin R, Del Valle DM, Calorossi S, Lansky A, Walker L, Patel M, Xie H, Yi N, Yu A, Kang G, Liharska LE, Moya E, Hartnett M, Hatem S, Wilkins L, Eaton M, Jamal H, Tuballes K, Chen ST, Chung J, Harris J, Batchelor C, Lacunza J, Yishak M, Argueta K, Karekar N, Lee B, Kelly G, Geanon D, Handler D, Leech J, Stefanos H, Dawson T, Scott I, Francoeur N, Johnson JS, Vaid A, Glicksberg BS, Nadkarni GN, Schadt EE, Gelb BD, Rahman A, Sebra R, Martin G; Mount Sinai COVID-19 Biobank Team, Marron T, Beckmann N, Kim-Schulze S, Gnjatic S, *Merad M
• A novel Cryo-EM structure enables development of selective cannabinoid receptor drugs
  Biochemistry 59, 1643-1644, (2020)
  Zilberg G, *Wacker D
• Nanobody-enabled monitoring of kappa opioid receptor states
  Nat Commun 11, 1145, (2020)
  *Che T, English J, Krumm BE, Kim K, Pardon E, Olsen RHJ, Wang S, Zhang S, Diberto JF, Sciaky N, Carroll FI, Steyaert J, Wacker D, *Roth BL
• VEGAS as a platform for facile directed evolution in mammalian cells
  Cell 178, 748-761, (2019)
  *English JG, Olsen RHJ, Lansu K, Patel M, White K, Cockrell AS, Singh D, Strachan RT, Wacker D, *Roth BL
• Structural determinants of 5-HT2B receptor activation and biased agonism
  Nat Struct Mol Biol 25, 787-796, (2018)
  *^$McCorvy JD, ^$Wacker D, ^$Wang S, Agegnehu B, Liu J, Lansu K, Tribo AR, Olsen RHJ, Che T, Jin J, *Roth BL
• How the ubiquitous GPCR receptor family selectively activates signalling pathways
  Nature 558, 529-530, (2018)
  Capper MJ, *Wacker D
• Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone
  Nature 555, 269-273, (2018)
  *Wang S, Che T, Levit A, Shoichet BK, *Wacker D, *Roth BL
• 5-HT2C receptor structures reveal the structural basis of GPCR polypharmacology
  Cell 172, 719-730, (2018)
  ^$Peng Y, ^$McCorvy JD, ^$Harpsoe K, Lansu K, Yuan S, Popov P, Qu L, Pu M, Che T, Nikolajsen LF, Huang XP, Wu Y, Shen L, Bjorn-Yoshimoto WE, Ding K, Wacker D, Han GW, Cheng J, Katritch V, Jensen AA, Hanson MA, Zhao S, Gloriam DE, *Roth BL, *Stevens RC, *Liu ZJ
• Structure of a nanobody-stabilized active state of the kappa opioid receptor
  Cell 172, 55-67, (2018)
  Che T, Majumdar S, Zaidi SA, Kormos C, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, Strachan RT, Tribo AR, Pasternak GW, Carroll IF, Stevens RC, Cherezov V, Katritch V, *Wacker D, *Roth BL
• ​D4 dopamine receptor high-resolution structures enable the discovery of selective agonists
  Science 358, 381-386, (2017)
  *^$Wang S, *^$Wacker D, ^$Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, *Shoichet BK, *Roth BL
• ​How ligands illuminate GPCR molecular pharmacology
  Cell 170, 414-427, (2017)
  Wacker D, Stevens RC, *Roth BL
• ​Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody
  Proc Natl Acad Sci USA 114, 8223-8228, (2017)
  Ishchenko A, Wacker D, Kapoor M, Zhang A, Han GW, Basu S, Patel N, Messerschmidt M, Weierstall U, Liu W, Katritch V, Roth BL, Stevens RC, *Cherezov V
• Crystal structure of an LSD-bound human serotonin receptor
  Cell 168, 377-389, (2017)
  *^$Wacker D, ^$Wang S, ^$McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools Z, Che T, Nichols DE, Shoichet BK, *Dror RO, *Roth BL
• An alerting structure: human orexin receptor 1
  Nat Struct Mol Biol 23, 265-266, (2016)
  ​Wacker D, *Roth B.L
• Femtosecond crystallography of membrane proteins in the lipidic cubic phase
  Phil Trans R So B 369, (2014)
  Liu W, Wacker D, Wang D, Abola E, *Cherezov V
• Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography
  Nat Commun 5, 3309, (2014)
  *Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, *Cherezov V
• ​Serial femtosecond crystallography of G protein-coupled receptors in lipidic cubic phase
  Science 342, 1521-1524, (2013)
  Liu W, Wacker D, Gati C, Han GW, James D, Wang D, Nelson G, Weierstall U, Katritch V, Barty A, Zatsepin NA, Li D, Messerschmidt M, Boutet S, Williams GJ, Koglin JE, Seibert MM, Wang C, Shah STA, Basu S, Fromme R, Kupitz C, Rendek KN, Grotjohann I, Fromme P, Kirian RA, Beyerlein KR, White TA, Chapman HN, Caffrey M, Spence JCH, Stevens RC, *Cherezov V
• ​Structure of the human glucagon class B G protein-coupled receptor
  Nature 499, 444-449, (2013)
  Siu FY, He M, de Graaf C, Yang D, Zhang Z, Zhou C, Han GW, Xu Q, Wacker D, Joseph JS, Liu W, Lau JF, Cherezov V, Katritch V, *Wang MW, *Stevens RC
• ​Structural basis for molecular recognition of serotonin receptors
  Science 340, 610-614, (2013)
  ^$Wang C, ^$Jiang Y, ^$Ma J, Wu H, Wacker D, Katritch V, Han GW, Liu W, Huang XP, Vardy E, McCorvy JD, Gao X, Zhou EX, Melcher K, Zhang C, Bai F, Yang H, Yang L, Jiang H, Roth BL, Cherezov V, *Stevens RC, *Xu HE
• ​Structural features for functional selectivity at serotonin receptors
  Science 340, 615-619, (2013)
  Wacker D, Wang C, Katritch V, Han GW, Huang XP, Vardy E, McCorvy JD, Jiang Y, Chu M, Siu FY, Liu W, Xu HE, Cherezov V, *Roth BL, *Stevens RC
• ​Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity
  ACS Chem Biol 7, 1184-1189, (2012)
  Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, *Liberles SD
• ​Structure of the human kappa-opioid receptor in complex with JDTic
  Nature 485, 327-332, (2012)
  Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, *Stevens RC
• ​GPCR stabilization using the bicelle-like architecture of mixed sterol-detergent micelles
  Methods 55, 310-317, (2011)
  Thompson AA, Liu JJ, Chun E, Wacker D, Wu H, Cherezov V, *Stevens RC
• ​Conserved binding mode of human β2 adrenergic receptor inverse agonists and antagonist revealed by X-ray crystallography
  J Am Chem Soc 132, 11443-11445, (2010)
  ^$Wacker D, ^$Fenalti G, ^$Brown MA, Katritch V, Abagyan R, Cherezov V, *Stevens RC
• ​Structural and functional analysis of Nup120 suggests ring formation of the Nup84 complex
  Proc Natl Acad Sci U S A 106, 14281-14286, (2009)
  Seo HS, Ma Y, Debler EW, Wacker D, Kutik S, *Blobel G, *Hoelz A

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